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The combination of esafoxolaner + eprinomectin + praziquantel (NexGard COMBO™) is a topical antiparasitic used to prevent heartworms and to prevent and treat intestinal parasites (hookworms, roundworms, and tapeworms), ear mites, fleas, and ticks (black-legged tick, lone star tick) in cats over eight weeks of age. This medication combination is currently only approved for use in Canada.
Its use in cats to treat skin mites is “off label”. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.
If you miss a dose, give it as soon as you remember, and then start a new monthly dosing schedule. For example, if you forgot to give your pet their dose on June 1 and remember on June 18, give the dose on June 18 and start a new schedule. You will give your cat the next dose on August 18. Do not give the pet two doses at once. Contact your veterinarian if you are concerned about a missed dose.
When used as directed in cats, side effects are uncommon, but may include:
Esafoxolaner belongs to the isoxazoline class of drugs, which have been associated with tremors and seizures.
EEP can also cause neurologic toxicity in cats with two copies of the MDR1 mutation. Signs may include:
Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately.
This long-acting medication is designed to work for at least four weeks. However, negative side effects are usually short-lived if they occur at all.
EEP should NOT BE USED in:
EEP should be USED WITH CAUTION in:
Specific interactions with EEP have not been reported. However, theoretical interactions may occur with some medications, including:
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your cat is taking.
No specific monitoring is required while your pet is taking this medication. Your veterinarian may monitor your pet to be sure that the medication is working.
If you suspect an overdose or adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.
© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Last updated on Jul 31, 2024.
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105 Winchester Rd. W Brooklin, Ontario, L1M 1B5
Mailing AddressBox 93, Brooklin, Ontario, L1M 1B5
Phone: 905-655-3811
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